When the activating button for a nuclear launch is lost at sea, it is up to James Bond to retrieve it before it falls into the wrong hands. Roger Moore once again plays 007 in this, the 12th Bond outing, director John Glen's first Bond film and the first without an Ian Fleming credit. Highlights include a climb up a sheer rock-face; a car chase down a steep, winding mountain road; an underwater battle; and what might be the greatest of all Bond's celebrated ski chase sequences.

Selling your CTO on the merits of OpenShift and Kubernetes is only the beginning. When it comes to operating and scaling OpenShift, you need to understand how to manage and expose resources to application teams and how to continuously deliver changes to applications running in these environments. With this practical book, new and experienced developers and operators will learn specific techniques and examples for operationalizing OpenShift and Kubernetes in the enterprise. Industry experts Michael Elder, Jake Kitchener, and Brad Topol show you how to run OpenShift and Kubernetes in production and deliver your applications to a highly available, secure, and scalable platform. You'll learn how to build a strong foundation in advanced cluster operational topics, such as tenancy management, scheduling and capacity management, cost management, continuous delivery, and more. This book shows you how to: Manage multiple teams in their use of OpenShift and Kubernetes Promote the efficient use of data center resources Deliver highly available applications and services Manage application tenancy throughout the enterprise Provide multicluster management and high availability Apply continuous updates to OpenShift and Kubernetes Devise and deliver disaster recovery strategies

With detailed contributions from 45 renowned international authorities, this Third Edition stands alone as the most comprehensive, contemporary view of the biology, physiology, and management of acute coronary syndromes (ACS)-offering 32 chapters that span the state-of-the science in the field and provide intriguing discussions on CRP and other disease markers, microcirculation, stem cell therapy, and the development of specialized centers for ACS treatment.

A visit to a physician these days is cold: physicians spend most of their time typing at computers, making minimal eye contact. Appointments generally last only a few minutes, with scarce time for the doctor to connect to a patient's story, or explain how and why different procedures and treatments might be undertaken. As a result, errors abound: indeed, misdiagnosis is the fourth-leading cause of death in the United States, trailing only heart disease, cancer, and stroke. This is because, despite having access to more resources than ever, doctors are vulnerable not just to the economic demand to see more patients, but to distraction, burnout, data overload, and their own intrinsic biases. Physicians are simply overmatched. As Eric Topol argues in Deep Medicine, artificial intelligence can help. Natural-language processing could automatically record notes from our doctor visits; virtual psychiatrists could better predict the risk of suicide or other mental health issues for vulnerable patients; deep-learning software will make every physician a master diagnostician; and we could even use smartphone apps to take our own medical "selfies" for skin exams and receive immediate analysis. . On top of that, the virtual smartphone assistants of today--Alexa, Siri, Cortana--could analyze our daily health data to reduce the need for doctor visits and trips to the emergency room, and support for people suffering from asthma, epilepsy, and heart disease. By integrating tools like these into their daily medical practice, doctors would be able to spend less time collecting and cataloging information, and more time providing thorough, intimate, and meaningful care for their patients, as no machine can. Artificial intelligence can also help remedy the debilitating cost of healthcare, both for individuals and the economy writ large. The medical sector now absorbs 20 percent of the US gross domestic product--it is largest sector by dollars and jobs. And it's very inefficient. Take the cost of medical scans: There are over 20 million medical scans performed in the US every day, and an MRI, for example, costs hundreds to thousands of dollars. AI could process 260 million medical scans (more than 2 weeks' worth) in less than 24 hours for a cost of only $1000. We pay billions and billions of dollars for the same work today. The American health care system needs a serious reboot, and artificial intelligence is just the thing to press the restart button. As innovative as it is hopeful, Deep Medicine ultimately shows us how we can leverage artificial intelligence for better care at lower costs with more empathy, for the benefit of patients and physicians alike.

A trip to the doctor is almost a guarantee of misery. You'll make an appointment months in advance. You'll probably wait for several hours until you hear "the doctor will see you now",but only for fifteen minutes! Then you'll wait even longer for lab tests, the results of which you'll likely never see, unless they indicate further (and more invasive) tests, most of which will probably prove unnecessary (much like physicals themselves). And your bill will be astronomical.In The Patient Will See You Now , Eric Topol, one of the nation's top physicians, shows why medicine does not have to be that way. Instead, you could use your smartphone to get rapid test results from one drop of blood, monitor your vital signs both day and night, and use an artificially intelligent algorithm to receive a diagnosis without having to see a doctor, all at a small fraction of the cost imposed by our modern healthcare system. The change is powered by what Topol calls medicine's "Gutenberg moment." Much as the printing press took learning out of the hands of a priestly class, the mobile internet is doing the same for medicine, giving us unprecedented control over our healthcare. With smartphones in hand, we are no longer beholden to an impersonal and paternalistic system in which "doctor knows best." Medicine has been digitized, Topol argues now it will be democratized. Computers will replace physicians for many diagnostic tasks, citizen science will give rise to citizen medicine, and enormous data sets will give us new means to attack conditions that have long been incurable. Massive, open, online medicine, where diagnostics are done by Facebook-like comparisons of medical profiles, will enable real-time, real-world research on massive populations. There's no doubt the path forward will be complicated: the medical establishment will resist these changes, and digitized medicine inevitably raises serious issues surrounding privacy. Nevertheless, the result,better, cheaper, and more human health care,will be worth it.Provocative and engrossing, The Patient Will See You Now is essential reading for anyone who thinks they deserve better health care. That is, for all of us.

Process tabular data and build high-performance query engines on modern CPUs and GPUs using Apache Arrow, a standardized language-independent memory format, for optimal performance Key Features Learn about Apache Arrow's data types and interoperability with pandas and Parquet Work with Apache Arrow Flight RPC, Compute, and Dataset APIs to produce and consume tabular data Reviewed, contributed, and supported by Dremio, the co-creator of Apache Arrow Book DescriptionApache Arrow is designed to accelerate analytics and allow the exchange of data across big data systems easily. In-Memory Analytics with Apache Arrow begins with a quick overview of the Apache Arrow format, before moving on to helping you to understand Arrow's versatility and benefits as you walk through a variety of real-world use cases. You'll cover key tasks such as enhancing data science workflows with Arrow, using Arrow and Apache Parquet with Apache Spark and Jupyter for better performance and hassle-free data translation, as well as working with Perspective, an open source interactive graphical and tabular analysis tool for browsers. As you advance, you'll explore the different data interchange and storage formats and become well-versed with the relationships between Arrow, Parquet, Feather, Protobuf, Flatbuffers, JSON, and CSV. In addition to understanding the basic structure of the Arrow Flight and Flight SQL protocols, you'll learn about Dremio's usage of Apache Arrow to enhance SQL analytics and discover how Arrow can be used in web-based browser apps. Finally, you'll get to grips with the upcoming features of Arrow to help you stay ahead of the curve. By the end of this book, you will have all the building blocks to create useful, efficient, and powerful analytical services and utilities with Apache Arrow. What you will learn Use Apache Arrow libraries to access data files both locally and in the cloud Understand the zero-copy elements of the Apache Arrow format Improve read performance by memory-mapping files with Apache Arrow Produce or consume Apache Arrow data efficiently using a C API Use the Apache Arrow Compute APIs to perform complex operations Create Arrow Flight servers and clients for transferring data quickly Build the Arrow libraries locally and contribute back to the community Who this book is forThis book is for developers, data analysts, and data scientists looking to explore the capabilities of Apache Arrow from the ground up. This book will also be useful for any engineers who are working on building utilities for data analytics and query engines, or otherwise working with tabular data, regardless of the programming language. Some familiarity with basic concepts of data analysis will help you to get the most out of this book but isn't required. Code examples are provided in the C++, Go, and Python programming languages.

A brutally funny, carnivalesque novel about love, death, and survival, from the Czech Republic's greatest living author Tab, an itinerant Czech actor, travels around Europe on the theater circuit with his partner, Sona, and their two young sons, attending festivals and performing plays. Confronted with growing resentment toward foreigners, Tab decides to return home to the banks of the Sazava River, southeast of Prague. As soon as they arrive, Tab finds himself falsely accused of a terrible crime and forced to go on the run with his sons. Over the course of their journey, dodging authorities by car, foot, and raft, they encounter a motley cast of allies and enemies. The effects of Tab's sudden reappearance and just-as-sudden disappearance ripple through the community, catalyzing a chaotic chain of events that reaches a final, raucous crescendo. Hailed as "a picaresque romp of black humor and fantasy" (Times Literary Supplement), this is an unforgettable novel about discovering sparks of humanity even in the bleakest of places, in which love or the longing to find it lies around every bend.

Now with a new postscript covering the unfolding health care revolutionMobile technology has transformed our lives, and personal genomics is revolutionizing biology. But despite the availability of technologies that can provide wireless, personalized health care at lower cost, the medical community has resisted change. In The Creative Destruction of Medicine , Eric Topol,one of the nation's top physicians,calls for consumer activism to demand innovation and the democratization of medical care. The Creative Destruction of Medicine is the definitive account of the coming disruption of medicine, written by the field's leading voice.

Angioplasty has completely transformed the treatment of coronary artery disease and is widely used, with more than 800,000 procedures performed worldwide per year. However, the enthusiasm for angioplasty is shadowed by restenosis, which remains a critical problem after the procedure, resulting in clinical recurrence in over a third of patients. Recently, the mechanisms of restenosis have been completely reappraised with an enriched understanding that the original concept of neointimal hyperplasia may not be accounting for the bulk of the problem. There is a desperate need to heighten understanding of the remodeling process at the molecular, cellular, and arterial level. Vascular remodeling is a well established concept in the field of atherosclerosis and hypertension, but only in recent years has its applicability to the field of restenosis become pivotal. Accordingly, the editors perceived the need to assemble the first book dedicated to the concept of coronary artery remodeling in restenosis, in order to clearly review the experiments leading to the remodeling hypothesis and integrate this with the neointimal hyperplasia (tumor) model for the development of the restenotic lesion. The authors of this book present their experience to facilitate the understanding of the mechanisms for coronary restenosis and remodeling. The various experimental models, clinical issues, and basic mechanisms are reviewed in detail, resulting in a fresh approach to a vexing clinical problem. Arterial Remodeling: A Critical Factor in Restenosis will be useful to the physician and trainee who have an interest in restenosis, and specifically in the major pathophysiologic process which determines the fate of arterial healing in patients following percutaneous coronary revascularization. It is hoped that this book will lay the foundation for more effective therapies that will reduce the chance of constrictive remodeling and improve the long-term efficacy of non-surgical coronary revascularization in the future.

Angioplasty has completely transformed the treatment of coronary artery disease and is widely used, with more than 800,000 procedures performed worldwide per year. However, the enthusiasm for angioplasty is shadowed by restenosis, which remains a critical problem after the procedure, resulting in clinical recurrence in over a third of patients. Recently, the mechanisms of restenosis have been completely reappraised with an enriched understanding that the original concept of neointimal hyperplasia may not be accounting for the bulk of the problem. There is a desperate need to heighten understanding of the remodeling process at the molecular, cellular, and arterial level. Vascular remodeling is a well established concept in the field of atherosclerosis and hypertension, but only in recent years has its applicability to the field of restenosis become pivotal. Accordingly, the editors perceived the need to assemble the first book dedicated to the concept of coronary artery remodeling in restenosis, in order to clearly review the experiments leading to the remodeling hypothesis and integrate this with the neointimal hyperplasia (tumor) model for the development of the restenotic lesion. The authors of this book present their experience to facilitate the understanding of the mechanisms for coronary restenosis and remodeling. The various experimental models, clinical issues, and basic mechanisms are reviewed in detail, resulting in a fresh approach to a vexing clinical problem. Arterial Remodeling: A Critical Factor in Restenosis will be useful to the physician and trainee who have an interest in restenosis, and specifically in the major pathophysiologic process which determines the fate of arterial healing in patients following percutaneous coronary revascularization. It is hoped that this book will lay the foundation for more effective therapies that will reduce the chance of constrictive remodeling and improve the long-term efficacy of non-surgical coronary revascularization in the future.

Not even Tolstoy would dare use the eyebrow-raising Russian you'll find in this wickedly humorous language guide by one of Russia's bestselling novelists today. Whether you're traveling to Russia for the first time or you are a student of the language, this indispensable book is your entree to the real and new Russian that has never been taught. You'll be armored with triple-decker curses and insults, endearments and expressions for situations ranging from high-level business meetings to cocktail parties to sexual encounters. Filled with words, idioms, and vulgarisms you won't learn in a classroom, plus twenty hilarious line drawings and a complete index to vital expletives, Dermo! will provide you with the uncensored answers to the questions you always wanted to know...but no translator would ever tell you!

Angel Station takes its title from the bustling Metro stop in the Prague district of Smichov. Until the gentrification of the late 1990s, it was a rough-and-tumble, working-class neighborhood with a sizeable Roma and Vietnamese population. Topol's novel, in sparse yet poetic language-agilely brought into English by the author's longtime translator Alex Zucker-weaves together the brutal and disturbing fates of an addict, a shopkeeper, and a religious fanatic as they each follow the path they hope will lead them to serenity: drugs, money, and faith.

Keystone-OpenStack's Identity service-provides secure controlled access to a cloud's resources. In OpenStack environments, Keystone performs many vital functions, such as authenticating users and determining what resources users are authorized to access. Whether the cloud is private, public, or dedicated, access to cloud resources and security is essential. This practical guide to using Keystone provides detailed, step-by-step guidance to creating a secure cloud environment at the Infrastructure-as-a-Service layer-as well as key practices for safeguarding your cloud's ongoing security. Learn about Keystone's fundamental capabilities for providing Identity, Authentication, and Access Management Perform basic Keystone operations, using concrete examples and the latest version (v3) of Keystone's Identity API Understand Keystone's unique support for multiple token formats, including how it has evolved over time Get an in-depth explanation of Keystone's LDAP support and how to configure Keystone to integrate with LDAP Learn about one of Keystone's most sought-after features-support for federated identity

When both his moms take an offer for a year of employment in Europe, fifteen-year-old David Martin has no choice but to head to Connecticut to stay with his dad and his dad's partner. Not only is he leaving behind the life he loves in New York City, he's unsure how he feels about staying with a father he barely knows, one who has been far from supportive during David's life. If he doesn't have enough on his plate, David is also confused and wrestling with his burgeoning sexual feelings… toward other boys. Running with his dad's partner takes the edge off, but training with the hot—and openly gay—track team captain, Kevin Ringer, produces a different kind of rush. An assault on David and Kevin in the locker room gives David a new perspective on his own identity, his feelings for Kevin, and his relationship with his dad. Life is very different from what David is used to, but he's determined to carve out a place for himself.

Razones claras, consejos y metodos para involucrar a los pacientes en su salud de una manera efectiva. El tercer libro del ePaciente Dave. Superviviente de de un cancer, bloguero y conferenciante internacional. Defensor de la participacion del paciente, co-fundador y ex presidente de la "Society for Participatory Medicine." www.ePatientDave.com/about-dave La web del libro: http: //epatientdave.com/let-patients-help

Kontseptsiya gisto-gematicheskikh bar'erov s razvitiem meditsiny priobretaet vse bol'shee znachenie v teoreticheskom i prakticheskom aspektakh. Biologicheskiy smysl i fiziologicheskoe funktsionirovanie gisto-gematicheskikh bar'erov v organakh i tkanyakh cheloveka svyazany s podderzhaniem gomeostaza zhiznenno vazhnykh organov. Eto unikal'nyy mekhanizm zashchity ot negativnykh faktorov vnutri organizma cheloveka. Naibolee polno izucheny mekhanizmy funktsionirovaniya gemato-entsefalicheskogo bar'era. Men'shee kolichestvo nauchnykh issledovaniy posvyashcheno funktsiyam gemato-platsentarnogo, gemato-oftal'micheskogo, gemato-labirintnogo, gemato-testikulyarnogo bar'erov. Izucheniyu funktsionirovaniya gemato-salivarnogo bar'era (GSB) posvyashcheno krayne maloe chislo rabot. Funktsionirovanie GSB imeet vazhnoe znachenie v etiologii, patogeneze, diagnostike, profilaktike i patogeneticheski obosnovannom lechenii mnogikh stomatologicheskikh zabolevaniy. Dannaya monografiya posvyashchena nekotorym aspektam funktsionirovaniya gemato-entsefalicheskogo (GEB) i gematosalivarnogo (GSB) bar'erov pri stomatologicheskikh i somaticheskikh zabolevaniyakh.

Rasshcheliny verkhney guby i neba zanimayut vtoroe mesto po chastote v strukture vrozhdennykh porokov i otnosyatsya k naibolee tyazhelym porokam razvitiya litsa i chelyustey, privodyashchim k znachitel'nym anatomicheskim, funktsional'nym i kosmeticheskim narusheniyam. Imeetsya tendentsiya k uvelicheniyu dannogo pokazatelya, odnoy iz prichin kotoroy yavlyaetsya rezkoe ukhudshenie ekologii. V rezul'tate etogo poyavlyaetsya mnozhestvo dopolnitel'nykh endogennykh faktorov, sposobstvuyushchikh vozniknoveniyu vrozhdyennykh anomaliy. Avtorami monografii izucheny etiologiya, patogenez, klinika, diagnostika vrozhdennoy rasshcheliny guby i nyeba, razrabotany novye metody profilaktiki i lecheniya v usloviyakh neblagopriyatnykh ekologicheskikh faktorov okruzhayushchey sredy.

Do nastoyashchego vremeni vopros vybora plasticheskogo materiala i metodiki zameshcheniya postrezektsionnykh defektov anatomicheskikh struktur grudnoy kletki ostaetsya diskussionnym. V knige predstavleny original'nye sposoby zameshcheniya postrezektsionnykh defektov perikarda, diafragmy, grudnoy stenki s ispol'zovaniem biosovmestimykh implantatov na osnove nikelida titana i osobennosti ikh integratsii s prilezhashchimi tkanyami. Pokazano, chto v oblasti zameshchennogo defekta formiruetsya edinyy tkanevoy regenerata, kotoryy ne zatrudnyaet rabotu serdtsa, ekskursiyu diafragmy i grudnoy stenki, obespechivaet anatomo-fiziologicheskoe vosstanovlenie dannoy oblasti. Opisany klinicheskie primery i posleoperatsionnoe vedenie bol'nykh posle plasticheskogo zameshcheniya defektov grudnoy kletki.Kniga predstavlyaet interes dlya torakal'nykh i plasticheskikh khirurgov, onkologov, a takzhe dlya nauchnykh rabotnikov, zanimayushchikhsya voprosami biosovmestimosti materialov.